ea0034p357 | Steroids | SFEBES2014
Idkowiak Jan
, Taylor Angela E
, O'Neil Donna M
, Subtil Sandra
, Vijzelaar Raymon
, Dias Renuka P
, Amin Rakesh
, Barrett Timothy G
, Kirk Jeremy W
, Shackleton Cedric H L
, Moss Celia
, Arlt Wiebke
Steroid sulfatase (STS) cleaves the sulfate moiety off steroid sulfates, including DHEAS, the inactive sulfate ester of the adrenal androgen precursor DHEA. Deficient DHEA sulfation, the opposite enzymatic reaction to that catalysed by STS, results in androgen excess by increased conversion of DHEA to active androgens. STS deficiency (STSD) due to deletions or inactivating mutations in the X-linked STS gene manifests with ichthyosis, but androgen homeostasis in STSD h...